To be used in conjunction with Caymans 5-OxoETE Receptor Polyclonal Antibody (Item No. 100025) to block protein-antibody complex formation during immunochemical analysis of 5-OxoETE. The 5-OxoETE receptor recognizes eicosatetraenoic acids and polyunsaturated fatty acids including 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OxoETE), which is the most potent ligand.1 5-OxoETE is a potent stimulator of chemotaxis for eosinophils and neutrophils that mediates its action via a putative G-protein coupled receptor (GPCR).2,3 The receptor couples to Gi/o to inhibit cyclic AMP production and to mobilize intracellular calcium.2,3 Northern blot analysis revEAls that the receptor is highly expressed on eosinophils and neutrophils, suggesting a key role in the inflammatory response.3 In addition, the protein can also be detected in tissues such as kidney and liver.2,3 Technical Information Synonyms R527 TG1019 Amino Acids human 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OxoETE) receptor C-terminal amino acids 408-423 Formulation 200 ug of peptide in 200 l TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide