Ammonium bicarbonate is used in the manufacture of porous plastics, ceramics, dyes, and pigments, fire extinguishers. It has been used in the preparation and isolation of neoglycoprotein conjugates. It is a good buffer for applications such as lyophilization and matrix assisted laser desorption and ionization (MALDI) mass spectrometry. It is utilized for the in-gel digestion of proteins by trypsin and in the MALDI mass spectrometric analysis of proteins.