TACE FRET substrate I that is derived from the cleavage sequence of pro-TNFa recognized by the TNFa-cleaving enzyme (TACE). TNFa is presumably shed from cell membranes by TNFa-cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF-convertase ; Tested Applications: HPLC; Reacts With: Human; Molecular Weight: 1573.8 Da; Purity: Greater than 98 % purifiedConjugation: Unconjugated