DPY-30 is a component of the MLL1 methylation complex, which interacts directly with Ash2L.1 In C. elegans, DPY-30 is required for dosage compensation in XX individuals, and its deletion or mutation is lethal. For XO individuals, DPY-30 is required for proper growth and development.2,3 DPY-30 is a homodimer in solution, and two monomers interact with one Ash2L monomer.4 Addition of DPY-30 to the MLL1, WDR5, RbBP5, and Ash2L complex results in a 2-fold incrEAse in methylation rate, from 300x the MLL1 basal rate to 600x the MLL1 basal rate.5Technical InformationSynonymsDPY-30-like proteinhDPY-30SAF19Purity95%Sourcerecombinant protein expressed in E. coliMW11.2 kDaFormulation50 mM Tris, pH 8.0, 100 mM sodium chloride, and 20% glycerolLicenseSUMOpro tag was used under non-exclusive license from LifeSensors, Inc.UniProt Accession Q9C005