HCV-N-G3/10 (residues 2-119) protein.The protein contains the HCV core nucleocapsid immunodominant regions, amino acids: 1-102.Hepatitis C Virus core proteins are purified by proprietarychromatographic techniques.The hepatitis C virus (HCV) core protein represents thefirst 191 amino acids of the viral precursor polyproteinand is cotranslationally inserted into the membrane of theendoplasmic reticulum (ER)Hepatitis C virus (HCV) core is a viral structural protein;it also participates in some cellular processes, includingtranscriptional regulation. However, the mechanisms ofcore-mediated transcriptional regulation remain poorlyunderstood. Hepatitis C virus (HCV) core protein isthought to contribute to HCV pathogenesis through itsinteraction with various signal transduction pathwaysIn addition, HCV core antigen is a recently developedmarker of hepatitis C infection. It is remarkably efficientat establishing persistent infection, suggesting that ithas evolved one or more strategies aimed at evadingthe host immune response. T cell responses, includinginterferon-gamma production, are severely suppressedin chronic HCV patients. The HCV core protein hasbeen previously shown to circulate in the bloodstream ofHCV-infected patients and inhibit host immunity throughan interaction with gC1qR, 100 ug