IGFBP5 is a secreted protein that is a critical member of the IGF axis. It binds IGF-1 and restricts it from accessing its cell-surface receptor (IGF-1R). This aids in regulation of cell growth, differentiation, and apoptosis.1 IGFBP5 also displays IGF-1 independent transactivational activity in the nucleus.2 Some tissues and cell types with higher levels of this protein include kidney, hEArt, placenta, and skeletal cells.3 Expression has also been reported in a variety of cancers, including mammary gland and neuroblastoma.1,4 IGFBP5 (272 amino acids) has a calculated molecular weight of 30.6 kDa. Reported glycosylation and phosphorylation sites may explain the band migration to 33 kDa.1,5 Caymans IGFBP5 polyclonal antibody is directed against a synthetic peptide sequence that partially overlaps the IGFBP5 region identified as a nuclEAr localization signal.2 Technical Information Formal Name 200 ug peptide in 200 l TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide Synonyms Insulin-Like Growth Factor-Binding Protein 5 Blocking Peptide IBP-5 Blocking Peptide IGF-Binding Protein 5 Blocking Peptide Formulation 200 ug of peptide in 200 l of TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide