To be used in conjunction with Caymans PHLPP polyclonal antibody (Catalog No. 10007191) to block protein-antibody complex formation during immunochemical analysis of PHLPP Protein kinase B/Akt is critical in regulating cell growth and dEAth. Phosphorylation of a serine residue (Ser473) in a C-terminal hydrophobic motif of Akt is known to be linked to some of the most common human cancers. PHLPP dephosphorylates the hydrophobic motif of Akt and thus reduces Akt activity, resulting in a incrEAse in the number of apoptotic cells.1 PHLPP levels are markedly reduced in several colon cancer and glioblastoma cell lines that have elevated Akt phosphorylation. Injection of a human glioblastoma cell line overexpressing PHLPP into mice reduced tumor size by nEArly 70% compared with control animals. mRNA of PHLPP is ubiquitously expressed, with highest levels found in brain.1 Technical Information Synonyms KIAA0606 Protein PHLPP PLEKHE1 Protein SCOP Suprachiasmatic Nucleus Circadian Oscillatory Protein Amino Acids PH Domain Leucine-rich RepEAt Protein Phosphatase (PHLPP) amino acids 1192-1205 (YQLDQLPDYYDTPL) Formulation 200 ug of peptide in 200 l TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide