To be used in conjunction with Caymans PTEN polyclonal antibody (Catalog No. 10005059) to block protein-antibody complex formation during immunochemical analysis of PTEN PTEN dephosphorylates proteins and lipids such as AKT and phosphatidylinositol 3,4,5-triphosphate (PIP3) and therefore functions as a key regulatory enzyme in a central signal transduction pathway. PTEN is expressed in almost all tissues of the body as a 403 amino acid protein with an estimated molecular weight of 47 kDa, however the actual migration observed on western blot may vary among distinct samples.1 PTEN interacts with many other proteins to regulate cell division and migration as well as promoting apoptosis when necessary.2 Mutation of PTEN results in many human cancers including melanoma and prostate carcinoma.3,4 Technical Information Synonyms Phosphatase and Tensin Homology on Chromosome 10 Amino Acids human PTEN amino acids 254-270 Formulation 200 ug of peptide in 200 l TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide