RNA Spin Column-TNSC-50-RNA is supplied Transiom Genomics. Isolating RNA using a spin column is widely used in many nucleic acid purification kits. It is a type of solid-phase extraction, where the principle relies on nucleic acid binding to a solid surface, such as silica gel. Once the cellular lysate is eluted, addition of buffers with varying conditions, such as in pH or salt concentration, facilitate nucleic acid binding and removal of unwanted particles.