Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function.1 Lysine residues can be mono-, di-, or tri-methylated, and unlike most SET proteins, SET7/9 is exclusively a mono-methylase.2 SET7/9 methylates histone H3, tumor suppressor p53, and transcription factor TAF10.3 Recently, SET7/9 was shown to catalyze methylation of p53 in response to DNA damage thereby activating p53 for subsequent acetylation.1 SET7/9 is able to modulate p53 activity in a human cancer cell line, implying that it may play a significant role in human tumorigenesis.Technical InformationSynonymsKMT7SETD7SETD7/9SET Domain-containing Protein 7/9Purity95% estimated by SDS-PAGESourceActive recombinant N-terminal His-tagged SET7/9 purified from E. coliAmino Acids1-366 (full-length)MW43.3 kDaFormulation50 mM HEPES, pH 7.2, 100 mM sodium chloride, and 20% glycerolUniProt Accession Q8WTS6