The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-dEAcetylases (class III HDACs) and have been shown to catalyze a rEAction that couples lysine dEAcetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group.1,2,3 There are seven human sirtuins, which have been designated SIRT1-7.4 SIRT6 associates specifically with telomeres and functions at chromatin to decrEAse NF-B signaling.5,6 Mammalian cells depleted of SIRT6 display abnormal telomere structures similar to defects found in Werner syndrome, a premature ageing disorder, and have a shortened life span.5,6 Since SIRT6 binds and attenuates NF-B signaling, it is proposed that activators of SIRT6 may be effective anti-cancer and anti-inflammatory drugs and may incrEAse longevity.5Technical InformationSynonymsNAD-dependent DEAcetylase 6Silent Information Regulator 6SIR2L6SIR2-like Protein 6Sirtuin 6Purity80% estimated by SDS-PAGESourceactive recombinant N-terminal His-tagged enzyme purified from E. coliAmino Acids1-355MW43.7 kDaUniProt Accession Q8N6T7