Positive Pressure System is a necessary requirement for Solid-phase Extractions. Solid Phase Extraction is the most common choice of sample preparation in comparison to other bioanalytical and bioequivalence methods. The system provides a set level of pressure for sample transfer, washing steps, drying before elution etc. The system offers reproducible results, higher recovery rates and efficient flow rates for extraction. The positive pressure system significantly improves the flow of viscous samples such as blood, serum through the packed bed.